Cartilage changes are common in knees that do not hurt. Across 63 studies of uninjured adults with no knee symptoms, 24 percent had a cartilage defect on MRI, rising to 43 percent over the age of 40 (Culvenor et al., 2019). In 230 knees of asymptomatic adults scanned at 3 tesla, cartilage abnormalities at the kneecap joint were found in 57 percent, and moderate or severe lesions were not rare (Horga et al., 2020).
People with kneecap pain and people without it look alike on MRI. In a study of 64 young adults with patellofemoral pain and 70 without, minor patellar cartilage defects were found in 23 percent of the patients and 21 percent of the controls, and no structural finding was linked with having the pain once age, sex, weight and sport were accounted for (van der Heijden et al., 2016). Chondromalacia on the report is not the explanation for the pain in most people.
The grade is not a pain score. Cartilage has no nerve supply of its own. The grade describes the surface, and a knee with a grade 2 change can hurt more than a knee with a grade 3 change. What tends to decide the pain is how much load the kneecap joint is taking relative to what it is currently used to.
It is not the same as arthritis of the knee. Chondromalacia describes cartilage at one joint surface. Patellofemoral osteoarthritis is a wider picture that includes bone changes, and most knees with chondromalacia on a report in a younger adult are not arthritic.
It is not expected to grow back. Cartilage has a limited ability to repair, and no routine treatment restores it. Pain and function improve without the scan changing, which is why follow-up scans are not part of the usual plan.