A Cochrane review describes Morton's neuroma as a non-cancerous enlargement of a nerve to the toes, most often in the third space between the toes and less often the second, causing burning or shooting pain in that space that spreads to the toes, or the feeling of walking on a pebble. It found only six randomised trials of any treatment, 373 people in all, none free of concerns about bias. Adding a steroid to a numbing injection may have made little or no difference to pain at three to six months, on low-certainty evidence; guiding the injection with ultrasound probably reduced pain compared with an unguided injection, and the steroid occasionally thinned the skin or the fat pad under the foot.
Matthews BG, Thomson CE, Harding MP, et al. "Treatments for Morton's neuroma." Cochrane Database Syst Rev 2024; 2(2): CD014687.
In 40 people (54 feet) diagnosed with Morton's neuroma from the history and examination, an ultrasound scan confirmed a neuroma at the same spot in 53 feet. Squeezing the sore space between thumb and index finger brought on the pain in nearly all of them, while Mulder's click was found in about 6 in 10 and more often with a larger neuroma. Squeezing the forefoot from the sides, tapping it, and testing feeling in the toes each picked up fewer than half. Everyone in the study had a neuroma, so it could not show how often these tests are positive in other forefoot problems.
Mahadevan D, Venkatesan M, Bhatt R, Bhatia M. "Diagnostic Accuracy of Clinical Tests for Morton's Neuroma Compared With Ultrasonography." J Foot Ankle Surg 2015; 54(4): 549-553.
In forefoot magnetic resonance imaging (MRI) scans of 70 adults with no foot symptoms, a thickening that met the scan criteria for a Morton's neuroma showed up in 21 of them (30%). These were smaller on average than 16 painful neuromas confirmed at surgery, but the sizes overlapped, and the authors suggested a scan finding may matter only when it is at least 5 mm across and matches the clinical findings. Small amounts of fluid in the little sacs between the bone ends (intermetatarsal bursae) were also common and can be normal.
Zanetti M, Strehle JK, Zollinger H, Hodler J. "Morton neuroma and fluid in the intermetatarsal bursae on MR images of 70 asymptomatic volunteers." Radiology 1997; 203(2): 516-520.
In the records of 90 people (109 feet) who had surgery to repair a torn plantar plate, most had pain that came on gradually, with pain and puffiness at the joint behind the second toe. A positive drawer test was found in about 8 in 10 of the tears seen at surgery and was rarely positive when no tear was found, and a toe crossing over its neighbour also pointed toward a tear. The authors note that these tears are frequently missed at the first examination. It was a look back at people who had surgery, so the figures may not hold for everyone with forefoot pain.
Klein EE, Weil L Jr, Weil LS Sr, et al. "Clinical examination of plantar plate abnormality: a diagnostic perspective." Foot Ankle Int 2013; 34(6): 800-804.
Of 45 people with metatarsalgia given simple custom metatarsal pad insoles at a Finnish hospital and followed for at least a year, 25 were interviewed, and their pain scores fell on average. Most were women, with an average age of 56; among the 25 interviewed, 40% wore high heels daily and 68% had done standing work for several years, and on X-rays 42 percent had a bunion and 47 percent arthritis changes at the big toe joint. There was no comparison group, so the study cannot show how much of the improvement came from the pads.
Männikkö K, Sahlman J. "The Effect of Metatarsal Padding on Pain and Functional Ability in Metatarsalgia." Scand J Surg 2017; 106(4): 332-337.
In 29 people diagnosed clinically with Morton's neuroma who had both MRI and ultrasound before surgery to remove the nerve, the clinical assessment was the most sensitive and specific of the three, and both scans were less accurate for small lesions. Because everyone had already been judged to have a neuroma, the study cannot show how well the examination separates a neuroma from other forefoot problems.
Sharp RJ, Wade CM, Hennessy MS, et al. "The role of MRI and ultrasound imaging in Morton's neuroma and the effect of size of lesion on symptoms." J Bone Joint Surg Br 2003; 85(7): 999-1005.
In 78 people (82 feet) who had the nerve removed and were followed for an average of 4.6 years, 82 percent reported an excellent or good result, 10 percent a fair result and 8 percent no improvement, and 71 percent had some restriction in the shoes they could wear. There was no comparison group.
Pace A, Scammell B, Dhar S. "The outcome of Morton's neurectomy in the treatment of metatarsalgia." Int Orthop 2010; 34(4): 511-515.